REVIVAL PRP® for Veterinary Medicine

SKU

835659002026

DIN

92099817

Size

11ml and 22ml Tubes

Indications

Indicated for the acceleration of bone and tissue healing

Directions

Intended for use only by physicians.

Categories: ,

WHAT IS REVIVAL PRP®?

REVIVAL PRP® is an Advanced Separator Gel-based, easy to use, sterile system that is used to prepare PRP in a safe and effective manner to accelerate the body’s own natural healing process.

PRP is used in various medical applications including tissue enhancement, tissue and cell regeneration, rejuvenation, reconstruction and for general healing and repair.

PRP is indicated for the following conditions:

  • ACL Rupture
  • Chronic and Surgical Wounds
  • Supraspinatus Tendinopathy
  • Fractures, bone defects and cavities
  • Chronic equine laminitis
  • Bursitis
  • Suspensory ligament lesions
  • Osteoarthritis and degenerative joint disease
  • Corneal ulcers
  • Desmitis
  • Cartilage and meniscal explants
  • Hip and elbow dysplasia
  • Distraction osteogenesis (limb lengthening)

COMMON CONDITIONS IN CANINE, FELINE AND EQUINE SPECIES

As an animal ages or engages in various activities, they are at risk for developing various degenerative joint diseases (DJD), tendinopathies and/or suffering from injuries that may develop into chronic wounds. Some common conditions that they may suffer from are:

Supraspinatus Tendinopathy
Supraspinatus tendinopathy (ST) is characterized by degeneration of the tendon fibers and occurs in young to middle-aged, large breed dogs with no gender predilection (Ho et al 2015) and is a common cause of forelimb lameness in dogs. The cause of ST is thought to be repeated strain and overuse from chronic repetitive activity, with a failure of adequate remodeling (Canapp Jr et al 2016). Extreme and rapid hyperflexion of the shoulder is likely the cause of tear or damage to the supraspinatus tendon.

Dogs are typically non-responsive to traditional treatments such as rest and NSAIDs, and additional reported treatment options such as rehabilitation therapy and surgery may not always be successful.

Following resolution of lameness, there is a lifelong increased susceptibility to re-injury due to the reduced strength of fibrotic scar tissue compared to the original tendon (Ho et al 2015).

Open Wounds
Open wounds in dogs can occur from a number of different causes. Abrasions or scrapes can occur when the superficial skin layers are damaged. This will cause minor inflammation, some surface bleeding and may cause bruising. Abrasions can occur from an animal biting at their skin, jumping over or digging under fences, fighting or being dragged across a rough surface.

Lacerations are when an animal’s skin has been cut or torn open. Some lacerations will have clean, smooth edges or they may have jagged edges. Some lacerations will affect multiple layers of tissue depending on what caused the actual laceration. Puncture wounds or bite wounds occur when an object or tooth pierces the skin and leaves a small hole in the surface.

The hole will most likely affect multiple layers of tissue and is most susceptible to bacterial infections. Puncture wounds can easily become abscessed, creating a bigger medical emergency for your client’s pet.

Superficial Digital Flexor Tendinopathy
The flexor tendons of horses’ lower limbs are important weight-bearing structures at rest and during locomotion. The anatomic arrangement of tendons and joints in the lower limb provides an efficient transfer of muscular energy for rapid locomotion. Of the two flexor tendons, the superficial digital flexor tendon (SDFT) is more commonly injured than the deep digital flexor tendon (DDFT). The SDFT provides a spring-like store of energy in the galloping horse and is subject to strains close to its mechanical limits, making it susceptible to overstrain injuries. Tendon damage may occur as a result of either overstrain of the tendon or a traumatic penetrating injury (O’Sullivan 2007).

It appears that the SDFT matures early, after which time it has limited ability to adapt to stress and undergoes progressive degeneration (Dowling et al 2000). Tendinopathy of the superficial digital flexor tendon (SDFT) is a common injury in Thoroughbred racehorses and other horse breeds and is regarded as a career limiting disease. Clinical injury is mostly strain induced and characterized by chronic degeneration after repetitive microtrauma in sport horses.

Tendinopathy may also be caused by a single external percutaneous trauma, such as a kick (Geburek et al 2016)

Degenerative Joint Disease

Degenerative Joint Disease (DJD) refers to arthritis or osteoarthritis, which is the result of the gradual deterioration of the articular cartilage within one or more the joints. This smooth resilient cartilage degenerates, becoming brittle over time. With severe DJD, the degenerated cartilage may actually split away from the bone and become loose within the joint. DJD can follow a number of joint diseases, including infection, and may develop after bone or joint injury or surgery.

Obese animals are more likely to develop DJD, as a direct result of the mechanical stress that excess weight puts on the joints. Although DJD is not usually an inflammatory disease, mild inflammation plays a part in causing clinical signs. When the cartilage cells become damaged, they release substances that result in inflammation, causing pain and further damage to the cartilage. Thus, once DJD begins, it can become a vicious cycle. Most of the damage caused by DJD is irreversible.

WHAT IS PRP?

Platelet Rich Plasma (PRP) is a portion of the animal’s own blood plasma that is concentrated in platelets and growth factors. These are critical in triggering the body’s regenerative mechanisms.

SOURCE OF PRP

The most basic method to prepare PRP is through centrifugation. The animal’s blood is drawn and centrifuged at a specific speed until it is separated into 3 layers: Platelet Poor Plasma (PPP), Buffy Coat/Platelet Rich Plasma (PRP) and red blood cells.

REVIVAL PRP’s Advanced Separator Gel sits in between the platelet-rich plasma and the red blood cells to ensure that the physician obtains a plasma preparation that is free from any red blood cells. Red blood cell contamination may provoke an inflammatory effect which can affect healing.

Depending on the application, calcium chloride is added to form a fibrin clot, which this then applied to the affected area

CHARACTERISTICS OF PRP

The platelets undergo degranulation to release Growth Factors (GFs) with healing properties. The plasma contains cytokines, thrombin, and other GFs with inherent biological and adhesive properties.

Growth Factors Present in Platelets and their Function

Transforming Growth Factor-beta

  • Stimulates undifferentiated mesenchymal cell proliferations
  • Regulates endothelial, fibroblastic and osteoblastic mitogenesis
  • Regulates collagen synthesis and collagenase secretion
  • Regulates the mitogenic effects of other growth factors
  • Stimulates endothelial chemotaxis and angiogenesis
  • Inhibits macrophage and lymphocyte proliferation

Basic Fibroblast Growth Factor

  • Promotes growth and differentiation of chondrocytes and osteoblasts
  • Mitogenic for mesenchymal stem cells, chondrocytes and osteoblasts

Platelet Derived Growth Factor

  • Mitogenic for mesenchymal stem cells and osteoblasts
  • Stimulates chemotaxis and mitogenesis in fibroblast/glial/smooth muscle cells
  • Regulates collagenase secretion and collagenase synthesis
  • Stimulates macrophage and neutrophil chemotaxis

Epidermal Growth Factor

  • Stimulates endothelial chemotaxis/angiogenesis
  • Regulates collagenase secretion
  • Stimulates epithelial/mesenchymal mitogenesis

Vascular Endothelial Growth Factor

  • Increases angiogenesis and vessel permeability
  • Stimulates mitogenesis for endothelial cells

Connective Tissue Growth Factor

  • Promotes angiogenesis, cartilage regeneration, fibrosis and platelet adhesion.

APPLICATIONS OF PRP IN DIFFERENT THERAPEUTIC AREAS

PRP has many different applications over a wide range of therapeutic areas such as Sports and Orthopedics, Dental, Cosmetic Surgery, Esthetics and Dermatology, General Surgery , Chronic Wounds, and Ophthalmology

SPORTS AND ORTHOPEDICS

Platelet Rich Plasma (PRP) is often used to treat a variety of chronic tendon, acute ligament and muscle injuries as well as other conditions such as arthritis and osteoporosis pain.

Sports

Athletes of all competition levels are early adopters of novel treatment methods. They are driven to find less invasive methods of injury management and faster means of returning to their sports.

Ligament, muscle and tendon tears are often slow to heal due to inadequate blood supply to these areas. Although PRP can be injected on any muscle or tendon, the following areas are the most common sites:

  • Shoulder (rotator cuff)
  • Elbow (Lateral or medial Epicondylitis; aka tennis or golfer’s elbow)
  • Knee (patellar tendon; aka Jumper’s knee)
  • Ankle (Achilles Tendon)

PRP can also be used during surgery to augment healing for ACL reconstruction and rotator cuff repair.

Connective tissues such as ligaments and tendons heal by filling in with scar tissue, which in turn, doesn’t support the pressure of large loads effectively and increases the risk of re-injury. Chronic tendon injuries are related to degeneration of the tendon tissue. Traditional forms of therapy do not necessarily improve the tendon’s ability to create new tissue and heal in the same way PRP does.

Platelets release bioactive proteins and growth factors which enhance tissue regeneration and healing. New tendon cells called tenocytes start to develop in the treated area. Cartilage cells called chondrocytes form when PRP is injected into damaged cartilage. There is also an increase in the number of growth factors in the treated area as well as a build-up of Type 1 collagen fibers, which constitute the base structure of tendon tissue. PRP has been demonstrated to shorten recovery time, decrease pain and improve performance in the injured area

  • Many high-profile athletes are also taking advantage of the benefits that PRP offers:
  • Kobe Bryant of the LA Lakers received more than three treatments on his knee in the past few years and was able to make a full comeback after serious injury
  • Alex Rodrigues of the New York Yankees received multiple PRP treatments for both his left shoulder and right knee
  • Peyton Manning (quarterback of the Denver Broncos) had several treatments to help repair ligaments, tissues and alleviate pain in his neck
  • Tiger Woods received PRP treatments for his Achilles tendon and both knees after a knee surgery to repair injury.

http://www.nbcnewyork.com/on-air/as-seen-on/New_Knee_Procedure_Gets_Athletes_Back_on_Track_New_York-106741583.html

(News coverage of PRP usage in athletes)

http://www.nytimes.com/2009/02/17/sports/17blood.html?pagewanted=all&_r=0

(Pittsburgh Steelers athletes use PRP as an innovative injury treatment)

Orthopedics

Some common orthopedic indications for which PRP is used are listed below:

  • Tendinopathies (refers to a degenerative condition of tendons characterized by the chronic loss of collagen, stability, strength and tissue integrity possibly  caused by natural aging, injury, repetitive stress, and/or neural, vascular and hormonal inputs)
  • Ligament Sprains
  • Muscle Strains
  • Joints (i.e. osteoarthritis; a chronic degenerative disease of hyaline cartilage)

PRP can be effective for many cases of osteoarthritis as repairing the damage has posed a great challenge due to its regenerative limitations. Platelets and other elements within the blood help tendons and ligaments heal by stimulating a repair and growth response that accelerates the process of developing new tissue. However, the tendons and ligaments do not receive a rich blood supply containing these factors which is why they often take a significant amount of time to heal. PRP stimulates healing of cartilage and reduces pain and disability by delivering these factors directly to the site of injury. Areas of treatment can include knee, hip, shoulder and ankle.

With age, the cartilage lining the joints can shrink and wear thin causing friction between the bones. Bone spurs and inflammation can gradually enlarge the joint leading to the pain and dysfunction of arthritis.

Damages to the cartilage have been treated by cortisone and HA injections, micro fracture, debridement and grafting procedures. The results obtained by these techniques are so far unsatisfactory and in most cases, result in the formation of fibrous connective tissue with minimal mechanical strength at the affected area.

Not only does PRP stimulate cellular activity and the process of regeneration and repair, it also improves bone and cartilage recovery, as well as reduce inflammation and pain which could potentially inhibit the deteriorating effects of age and slow the progression of arthritis.

The primary goal of PRP is to resolve pain through healing, therefore, it could prove to have lasting results. Initial improvement may be seen within a few weeks and gradually increase as healing progresses. Research studies and clinical practice have demonstrated PRP injections to be very effective at relieving pain and returning patients to their normal lives.

Ultrasound and MRI imaging have both shown definitive tissue repair after PRP therapy thereby confirming the healing process. The need for surgery can also be greatly reduced by treating injured tissues before the damage progresses to an irreversible condition.

DENTAL
 PRP can be used to accelerate autologous grafts used for site preparations, sinus lifts, osteointegration, ridge augmentations, etc. An enhanced bone regeneration can be expected when PRP is used with mixtures of autologous bone and bone substitutes and with recombinant human growth factors such as recombinant BMP. PRP has also been shown to increase the quantity and quality of the host bone in areas of localized alveolar defects when used for guided bone regeneration.

Early results are promising that PRP placed in the preparation site of a dental implant will promote and accelerate osteointegration. This may be beneficial in the maxilla, in areas of previous failures, in type IV bone, in osteoporotic women, etc.

COSMETIC SURGERY, ESTHETICS & DERMATOLOGY

PRP combined with  ultra-pulsed fractional CO2 laser had a synergistic effect on PRP therapy for facial rejuvination (Hui et al, 2007). Combined application:

  1. Effectively reduces facial wrinkles
  2. Significantly improves skin texture and elasticity
  3. Relieves coarse pores, pigmentation, and erythema caused by laser therapy.

Other clinical studies have demonstrated that PRP induces the proliferation of new fibroblasts within the first few hours. PRP treatment  resulted in notable increased rates of fibroblast migration and also induces the synthesis of collagen fibres that are of higher density and quality.

GENERAL SURGERY

Platelet rich plasma contains the bioactive proteins which act as the catalyst for accelerating the wound healing process. With the increased level of growth factors present in PRP, the tissue maturation phase is accelerated and the overall healing process is significantly improved in terms of post-operative pain, swelling, infection and establishment of tissue texture, colour and contour. PRP’s cohesive nature and its hemostatic properties also allow for minimal bleeding.

CHRONIC WOUNDS
Application of PRP yielded adequate hemostasis if PPP was also applied to create a seal to halt bleeding, because PPP contains much higher amounts of fibrinogen.
OPHTHALMOLOGY

Growth factors found in PRP permit accelerated tissue regeneration. It can be used to treat corneal lesions and dystrophy, superficial punctuate keratitis, severe dry eye-related ocular surface disorders, ocular GvHD, recurrent erosion syndrome, neurotrophic keratopathy, keratopathy with loss of epithelial-stromal tissue resulting from chemical or physical traumas, sicca syndrome and/or Sjögren’s syndrome.

It also provides nutritional factors necessary to maintain cellular feasibility in the epithelial repair process while reducing the risk of contamination and infection.

CLINICAL TRIALS

PLATELET-RICH PLASMA THERAPY FOR OSTEOARTHRITIS TREATMENT IN DOGS

Administration of a single intra-articular injection of autologous PRP resulted in significant improvements in dogs suffering from OA involving a single joint

(Click here to download full article)


The purpose of this trial was to determine the efficacy of a single IA injection of an autologous platelet concentrate for treatment of osteoarthritis in dogs. Dogs were randomly assigned to a treatment or control group. Dogs in the treatment group were then sedated, and a blood sample (55 mL) was obtained. PRP was then injected intra-articularly within 30 minutes. Control dogs were sedated and given an intra-articular injection of saline (0.9% NaCl) solution. Assessments were repeated 12 weeks after injection of platelets or saline solution.

For control dogs, lameness scores, pain scores, and PVF at week 12 were not significantly different from pre-treatment values. In contrast, for dogs that received platelet injections, lameness scores (55% decrease in median score), pain scores (53% decrease in median score), and PVF (12% increase in mean PVF) were significantly improved after 12 weeks, compared with pre-treatment values

It was concluded that in dogs suffering from OA involving a single joint, administration of a single intra-articular injection of autologous platelets resulted in significant improvements 12 weeks later, as determined by subjective (ie, owner-assigned scores for severity of pain and lameness) and objective (ie, PVF) measures.

PLATELET-RICH PLASMA TREATMENT IN EQUINE NATURALLY OCCURRING SUPERFICIAL DIGITAL FLEXOR TENDINOPATHIES

A single intralesional treatment with PRP contributes to an earlier reduction of lameness and to an advanced organization of repair tissue

(Click here to download full article)


The purpose of this trial was to evaluate the effect of a single treatment of equine superficial digital flexor tendon (SDFT) disease with PRP on clinical and ultrasonographic parameters

Using a placebo-controlled clinical trial design, 20 horses with naturally occurring tendinopathies of forelimb SDFTs were randomly assigned to the PRP-treated group (n = 10) or control group (n = 10) after clinical and ultrasonographic examination. The SDFTs received an intralesional treatment with autologous PRP or were injected with saline, respectively (day 0).

Compared to day 0, lameness decreased significantly by week 8 after treatment with PRP and by week 12 in the control group. Ultra-sonographically there was no difference in the summarized cross-sectional area between the groups at any time point.

Ultrasound tissue characterization showed that echo types representing disorganized matrix decreased significantly throughout the observation period in the PRP-treated group.

Echo type II, representing discontinuous fascicles, not yet aligned into lines of stress was significantly higher 24 weeks after PRP treatment. 80% of the PRP treated horses reached their previous or a higher level of performance after 12 months compared to 50 % in the control group.

A single intralesional treatment with PRP up to 8 weeks after onset of clinical signs of tendinopathy contributes to an earlier reduction of lameness compared to saline treatment and to an advanced organization of repair tissue as the fibrillar matrix is getting organized into fascicles while remodelling continues.

Long-term, PRP treatment has the potential to increase the number of horses reaching their previous level of performance. Earlier treatment of tendinopathy with PRP should be considered to enhance these effects


PLATELET-RICH PLASMA APPLICATION ON CUTANEOUS WOUND HEALING IN DOGS

PRP treated wounds showed more granulation formation and angiogenesis, faster epithelialization and collagen deposition than control wounds.

(Click here to download full article)


This study was conducted to identify the effectiveness of platelet-rich plasma (PRP) and efficacy of intralesional injection as a method of application to acute cutaneous wounds in dogs

Autologous PRP was separated from anticoagulant treated whole blood in three dogs. Cutaneous wounds were created and then treated by intralesional injection of PRP in the experimental group, while they were treated with saline in the control group on days 0, 2 and 4. The healing process was evaluated by gross examination throughout the experimental period and histologic examination on day 7, 14 and 21.

In PRP treated wounds, the mean diameter was smaller and the wound closure rate was higher than in the control. Compared with control wounds, total granulation indexes of PRP-treated wounds were increased on days 7 (p = 0.040) and 14 (p = 0.031).

The upper granulation index of PRP-treated wounds on Day 7 was significantly higher (p = 0.006) than that of the control while on day 14, the lower granulation index of the PRP-treated group was higher (p = 0.000)

The number of vessels was highest on day 7 in both the control and PRP-treated wounds and decreased gradually over the experimental period. More vessels were observed in the PRP-treated wounds than the control wounds on day 7 (p=0.0000). On day 7, PRP-treated wounds also displayed more collagen fibers than control wounds. The collagen fibers in all of the PRP-treated groups became denser and more abundant than those in the control group on day 14.

At day 21, most of the midportions and all of the upper portions of the dermis in PRP-treated wounds showed tightly packed collagen fibers running parallel to each other and the epidermis relative to control wounds.

RESOURCES FOR PET OWNERS

Xediton Pharmaceuticals offers a variety of services and resources to pet owners

FIND A VETERINARIAN
The following colleges and associations offer a tool on their websites that allow pet owners to locate a veterinarian in their area. Click the link below to locate a vet near you
ProvinceCollege/Association
British ColumbiaCollege of Veterinarians of British Columbia
AlbertaAlberta Veterinary Medical Association
SaskatchewanSaskatchewan Veterinary Medical Association
ManitobaManitoba Veterinary Association
OntarioCollege of Veterinarians of Ontario
QuebecOrdre des Médicins Vétérinaires du Quebec
New BrunswickNew Brunswick Veterinary Medical Association
NewfoundlandNewfoundland and Labrador Veterinary Medical Association
Nova ScotiaNova Scotia Veterinary Medical Association
Prince Edward IslandPEI Humane Society
REIMBURSEMENT
If you have insurance for your pet, please contact the insurance company to see if PRP Therapy is covered.
PRESCRIBING INFORMATION

Click here to download full Prescribing Information for Revival PRP®

EDUCATIONAL VIDEOS

PRP Therapy for horses


Platelet-rich Plasma Therapy Explained


 

EDUCATIONAL LINKS

Platelet Rich Plasma: Its Place in Cranial Cruciate Ligament Repair

For cranial cruciate ligament ruptures (CCLR) in small animals, surgery has typically been the only option. Click here to learn about how PRP therapy is a potentially beneficial adjunct treatment to surgery. This article talks about both the clinical benefits as well as limitations of PRP use in small animals with CCLR.

Platelet Rich Plasma Therapy for Healing Dog Injuries

For many canine injuries, platelet-rich plasma has shown promising results in optimizing the healing environment after an injury. Click here to read more.

Mending Tendon and Joint Injuries in Horses with PRP

Early treatment and rehabilitation techniques are key to successful platelet-rich plasma therapy.  Click here to learn how injecting PRP into a lesion within a few days of injury can stop the progression and growth of a lesion and prevent scar tissue formation

Platelet-rich Plasma: Improving Treatment for Tendon and Ligament Injuries in Horses

With recent advances made in the field of regenerative medicine, platelet-rich plasma therapy is becoming a more widespread treatment option offering vastly improved healing. Click here to read how this approach works to create real tendon tissue instead of scar tissue.

BROCHURES

 

Click here to download the Revival PRP® Patient Brochure

 

 

NEWSLETTER

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FREQUENTLY ASKED QUESTIONS

What is PRP?
Platelet-rich Plasma (PRP) is a portion of the plasma fraction (fluid component of blood) of blood that has a platelet and growth factor concentration above baseline to stimulate and boost the body’s natural healing process.
How does PRP work?
During PRP treatment, the animal’s blood is drawn and centrifuged in order to separate and concentrate the platelets and growth factors that are essential for tissue healing.

PRP is then injected or applied directly into the injured area causing the platelets and growth factors to activate. There is also recruitment of other healing proteins and factors to the area resulting in the healing and regeneration of tissue.

What is PRP used for?
PRP is used to accelerate healing and reduce pain by enhancing the body’s innate ability to repair and regenerate in a significantly shorter period of time.
How effective is PRP?
PRP has demonstrated efficacy and effectiveness in a number of different indications. Multiples studies have been published regarding the use of PRP with excellent results.
Is PRP safe?
Yes, the use of PRP is safe. There is minimal risk involved because the treatment uses the animal’s own blood plasma and platelets.
PRP is autologous and does not provoke an immune response and is therefore perceived to have a high margin of therapeutic safety (Textor 2014).

Since PRP is prepared from autologous blood, theoretically there are minimal risks for disease transmission or immunogenic reactions (Wang-Saegusa et al. 2011).
Adverse effects are rare, however, there is always a small risk of injection site morbidity, infection or injury to nerves or blood vessels. Scar tissue formation and calcification at the injection site have been reported as well (Dhillon et al. 2012).

It is also very rare that development of antibodies against clotting factors V and IX leading to life-threatening coagulopathies have been reported. However, to date there is no compelling evidence of any systemic effects of a local PRP injection (Dhillon et al. 2012).

Acting growth factors also attach to cell surfaces rather than to the nucleus, which minimizes the chance of tumor formation using a negative feedback control (Ko 2010).

Why use PRP injections?
PRP injections offer an alternative to surgery and are an ideal choice for pet owners who prefer a less invasive option or those who have pets that are unable to undergo a surgery. It also allows for a quick recovery and is less painful than surgery.
What are the advantages and benefits of PRP therapy?
Some advantages of PRP include an increase in collagen production, elimination of donor transmissible disease, its non-allergenic properties, and its ability to aid in tissue regeneration and rejuvenation.

Pet owners can see a significant improvement in symptoms and function in as little as two to three weeks. It reduces pain, increases mobility and increases flexibility as the treatment works to heal the injured or dysfunctional area. This may eliminate the need for more aggressive treatments such as long-term medication or surgery.

What are the risks of the procedure?
Since PRP treatment uses the animal’s own blood, there are very few risks associated. While infection is possible, the risks are very remote. The procedure should always be performed by an experienced professional with extensive training to minimize potential risks.
What are the adverse effects of PRP?
Infection, bruising and pain in the injected area are possible side effects of PRP treatment. In some very rare cases, an allergic reaction or blood clot is possible (due to the risk of damaging a vein).
What types of problems can be treated?
REVIVAL PRP® is indicated for the acceleration of bone and tissue healing in a wide array of muscle-skeletal conditions such as:

• Tendonitis
• Arthritis
• Ligament sprains or tears
• Bursitis
• Hip dysplasia
• Elbow dysplasia
• Muscle tears
• Chronic wounds

Who is a candidate for PRP treatment?
Animals with moderate injuries and/or have failed conservative treatments (i.e. medication, physical therapy, etc.) are potential candidates for PRP treatment. PRP is ideally used where faster healing, increased wound strength, pain relief, and reduced scarring is desired. Your veterinarian may recommend REVIVAL PRP® be used in tendon/ligament injuries, joint injuries, for wound healing, or for an injury where there is a need for increased blood flow.
Does PRP cure or just provide temporary relief?
PRP is perceived to heal the injured area by enhancing the natural regenerative process. Therefore, PRP cures and is not just a temporary solution to an injury.
How long does PRP therapy take to work?
Treatment time will depend on the condition treated, extent of the damage and each animal’s unique profile, however, results from multiple studies show positive results as soon as the first week and up to 6 weeks post procedure.
Is PRP therapy painful?
There is a possibility of soreness after the injection due to the PRP induced inflammatory response, especially if a joint was injected. This soreness is a positive sign that a healing response has been set in motion. This effect can last for several days and gradually decreases as healing and tissue repair occurs. The animal can resume normal activity, simply following a suggested rehabilitation plan. Vigorous or intensive exercise during this period is not recommended.
How many rounds of therapy are usually needed?
It will depend on the extent of the injury and the type of procedure being performed. Typically animals may need 1-2 injections for optimal results.
How long will PRP treatment results last?
PRP treatment is intended to resolve pain and promote healing of damaged tissue, therefore results could prove to be long lasting. Initial improvements may be evident within the first few weeks following treatment and continue throughout the healing process. In some cases, it can last up to a year or more.
Can PRP be used in conjunction with other treatments?
PRP has been used in conjunction with other therapies such as stem cells and skin grafting with outstanding results.
How much blood is required?
Depending on the injury, the animal and the procedure being performed, approximately 8-10 mL is obtained through a simple blood draw. The blood is centrifuged to produce PRP and the platelets are then collected in a syringe leaving 3-5cc to be injected at the required site. The entire procedure should take about 15-30 minutes.
Equine PRP preparations will require more blood (about 20ml) to yield approximately 12-14ml of plasma.
How soon can my animal return to normal and athletic activities?
Return to normal and athletic activity depends on the type and site of injury. Most chronic tendon injuries that have failed to respond to any other type of treatment will generally take quite a few weeks to heal. Injections into joints and acute muscle injuries heal quicker. Wounds will also require a few weeks to completely heal and close. Your veterinarian will inform you, based on the specific injury, what steps you and your animal should take for an effective recovery process.
How long does the procedure take?
The whole procedure takes approximately 30-45 minutes (depending on the application), including preparation and recovery time.
What can I do for my pet after the procedure?
Once the numbing effects of anesthesia subside, your pet will experience some soreness at the site of the treatment. As with most pain, icing the injection area for 15 minutes 2-3 times a day for the first few days will help ease the pain and inflammation. Most pets experience noticeable improvement in their mobility within a week or two and can resume normal activity.
Is PRP right for my animal?
If your animal has a tendon or ligament injury, degenerated joints or a chronic wound that does not appear to be healing in a timely manner, and traditional methods have not provided lasting relief, then PRP may be the solution. It helps to heal tissue with minimal or no scarring and alleviate further degeneration. The procedure is non-invasive, less expensive than surgery, and may eliminate the need for long-term and potentially harmful medication use. Talk to your veterinarian about whether PRP is right for your animal’s specific condition.
How much does the PRP treatment cost?
The cost of treatment depends heavily on a variety of factors such as the type of procedure, condition being treated and number of injections administered/required.
Can PRP cause infection?
PRP is in fact bactericidal (a substance that kills bacteria). While platelets are increased during PRP processing, leukocyte (white cells that fight infection) concentration is increased 6 to 8 times. This is one reason why PRP is so effective in wound healing. Not only do the increased leukocyte levels enable the body to fight off infection, they also have a dual purpose. After platelets initially release their growth factors, they produce a secondary release of leukocytes or growth factors to promote healing.
Can PRP cause cancer?
PRP has no ability to induce tumor formation and has never done so (Marx, RE, 2001), (Schmitz et al., 2001). The growth factors immediately bind to the external surface of the cell membranes of cells in the graft, flap, or wound via transmembrane receptors. The importance of this is that the GWP growth factors never enter the cell or its nucleus, they are not mutagenic, and they act through the stimulation of normal healing, just at a much faster rate.
Is it necessary to have more than one treatment? How often does this treatment need to be repeated?
It will depend on the condition treated, extent of the damage and the animal’s unique profile. While responses to treatment vary, most animals require 1 to 3 sets of injections; with majority of animals only needing 1 injection. If additional injections are necessary, the risks and side effects do not change.
Why is PRP such a great tool in wound care?
Platelets and inflammatory cells are the first to arrive at any site of injury and express and release growth factors that promote tissue repair and influence processes such as angiogenesis, inflammation and the immune response. Chronic wounds have been shown to stall in the inflammatory phase of wound healing and either do not heal or continue to deteriorate. By applying PRP which contains a higher than normal concentration of platelets to a site of injury, the healing process is accelerated and helps transition difficult to treat chronic wounds out of the inflammation phase and into the proliferative phase of healing.
How is REVIVAL PRP® different?
There are many advantages of the REVIVAL PRP® system which are likely reasons why your veterinarian is using this as the preferred system for your animal:

 

• REVIVAL PRP® has an advanced separator gel technology which allows for separation of the red and white blood cells so that only the plasma rich in healing platelets and proteins will be injected into the animal. The unique properties of the gel trap pro-inflammatory granulocytes below the gel. These granulocytes do not help regeneration and may contribute to a catabolic effect, so it is an ideal system when a veterinarian recommends it for your animal’s joint injury.

• REVIVAL PRP® is a sterile and closed system, ensuring that your vet obtains a clean PRP preparation each time.

How can my vet order the product?
REVIVAL PRP® may be ordered online by your vet through our website, fax or by phone. Our Customer Service Department is always ready to help fill your vet’s order, answer any questions and provide additional details regarding shipping and handling.
What should I do if my pet experiences an adverse reaction?
If your pet experiences an adverse reaction, please contact your veterinarian immediately.