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Weight0.072 kg
Dimensions3.2 x 8.4 cm





30 mL

Recommended Use

Helps support and boost immune function


Take 2.5 mL (half a teaspoon) with a meal once daily

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LENTINEX® is a natural health product extracted from Shiitake mushrooms. LENTINEX® optimizes immune cell performance to build a more resistant immune system.

LENTINEX® contains a triple helix ß-glucan structure that increases antibody production. In published research, ß-glucans have been shown to have antiviral, antibacterial and antifungal activity.

 Helps support and enhance immune system function

  • Increases fitness and energy
  • Increases B-cells for more antibody production
  • Provides more Natural Killer cells to combat viruses and bacteria

If you are looking to boost immune system performance, LENTINEX® may be a suitable option for you.

Medicinal Ingredients (per mL): ß-Glucan (Letinula edodes – mycelia)       1mg

LENTINEX® contains NO stimulants, yeast, dairy or artificial colours. It is mild and well tolerated.

Cautions: Keep out of reach of children. Pregnant and breastfeeding women are advised to consult with their healthcare practitioner prior to using this product.

Storage: Store in a dry place

Safety and drug interactions: LENTINEX® is safe, effective, and clinically proven to enhance immune system function. For use beyond 6 weeks, consult a health care practitioner. Consult a health care practitioner prior to use if you are pregnant or breastfeeding, suffer from an autoimmune system disorder or if you are taking immunosuppressants.

How Does it Work?

Cellular experimental models and animal studies have demonstrated that the extracts of Shiitake mushroom have antiviral and anti-tumour properties (Jong et al., 1993). These properties occur through the stimulation of immune cell maturation, differentiation or proliferation in host defence mechanisms against cancer or Infection (Chihara et al., 1989).

Lentinan is able to improve immune cell function through the activation of natural killer cells and the stimulation of helper T cells. Natural killer cells are a type of white blood cells, which protect against viral Infections as well as the formation of tumours within cells. Helper T cells support the immune activity of other cells by releasing cell signaling proteins that modulate activity between the cell based and humoral immune responses. Additionally, Lentinan inhibits the synthesis of prostaglandins, which are normally responsible for slowing T cell differentiation, and affects suppressor T-cell activity. Lentinan stimulates peripheral blood lymphocytes in vitro to increase IL-2-mediated lymphokine-activated killer cell and natural killer cell activity. Increased production of interleukins have also been observed with lentinan supplementation. These cells are responsible for promoting the development and differentiation of T and B-cells. Lentinan is able to act as a T-cell immune adjuvant, to restore and potentiate helper T-cell functions.

What are ß-Glucans?

Lentinan, a β-glucan is the main biologically active substance found within medicinal Shiitake mushrooms (Letinus edodes). It is characterized as a high molecular weight polysaccharide organized in a triple helix structure. These mushrooms have long traditional uses within Asian cultures for their various medicinal properties, which include its anti-thrombotic activity and its ability to reduce blood cholesterol levels. ß-glucans are able to directly activate leukocytes to stimulate phagocytic, cytotoxic and antimicrobial activity as well as the production of pro-Inflammatory mediators, which are necessary to effectively eliminate pathogens from the body.

When injected or given orally, Lentinan is generally considered safe. Animal studies have been used to evaluate the safety and immune-enhancing effects of LENTINEX® in mice, rats, chickens and pigs. A significant increase in white blood cells and immune cell signaling proteins were observed in rats. No signs of toxicity were observed.

How can LENTINEX® help?

Lentinan, the bioactive ß-glucan in LENTINEX® has been shown to elicit positive immune system enhancement effects that are associated with an improved ability to fight Infections.

These include:

  • Activation of Natural Killer-Cells
  • Increased production of B-cells (CD19+) and Lymphokine-Activated Killer cells
  • Increased production of cytokines such as interleukins (IL-1ɑ and IL-1ß) and interferon-ɣ (IFN-ɣ)

Suppression of prostaglandins leading to increased T-cell differentiation and suppressor T-cell activity

Who can benefit from LENTINEX®?

  • All adults
  • Anyone looking to improve their overall immune function


GlycaNova has developed a sophisticated production technology based on the cultivation of mushrooms in aseptic, submerged liquid cultivation allowing for the production of a lentinan ingredient, LENTINEX®. A stable, pure culture of Letinus edodes and other commercially available ingredients as nutrients are cultivated in carefully controlled fermentation conditions such as temperature, aeration rate, and pH. This helps to ensure that the growth and physiology of the organism are completely controlled to produce a constant supply of a clear product of a defined composition.

Following fermentation, the biomass is removed, leaving the cell free liquid, which is the raw material for the polysaccharide-based products. LENTINEX® is then heat sterilized and sodium benzoate (0.1%) may be added to preserve the product and allow for long-term storage even after the consumer has opened the product.

Regulatory Status and Quality Control

Quality Assurance and Control

The production of LENTINEX® is carried out according to current Good Manufacturing Practices (cGMP) regulations. All raw materials used for the fermentation process are all of food grade quality with certificates from the supplier. Samples of the culture broth are taken during fermentation to test for sterility. Batch records are prepared during the process according to the Standard Operating Procedure (SOP). The final product is again analyzed in the QC laboratory using the procedures stated above. A certificate of analysis is prepared based on the analytical results.


The immune system is viewed as a network of cells, proteins and tissues, which protects individuals from millions of foreign microorganisms such as viruses, bacteria and fungi. Its diverse and intelligent mechanisms allow it to distinguish pathogenic agents from healthy self-cells.

The key to a healthy immune system is its remarkable ability to distinguish between the body’s own cells—self—and foreign cells—non-self. The body’s immune defenses normally coexist peacefully with cells that carry distinctive “self” marker molecules. But when immune defenders encounter cells or organisms carrying markers that say “foreign,” they quickly launch an attack. Anything that can trigger this immune response is called an antigen.

Antibodies ambush antigens circulating the bloodstream. An antigen matches an antibody much as a key matches a lock. Some match exactly; others fit more like a skeleton key. But whenever antigen and antibody interlock, the antibody marks the antigen for destruction. An antigen can be a microbe such as a virus, or even a part of a microbe.

Tissues or cells from another person (except an identical twin) also carry non-self markers and act as antigens. This explains why tissue transplants may be rejected.

The immune system is governed by two responses – innate and adaptive. The innate system, otherwise known as the first line of defense is non-specific.  Common forms of barrier include our skin, tears, saliva and mucus. Cells, which play a role within the innate system, include macrophages and natural killer (NK) cells.


Macrophages are found under your skin, where they provide protection against invaders which penetrate this barrier and gain entry into your tissues (e.g., as the result of a wound or a burn). Macrophages also are present in your lungs, where they defend against inhaled microbes. Every once in a while, however, some of these resting macrophages receive signals which alert them that the barrier defense has been penetrated, and that there are intruders in the area. When this happens, they become activated or “primed”. Although a number of different signals can prime a resting macrophage, the best studied is an intercellular communication molecule (cytokine) called interferon gamma (IFN-γ). This cytokine is produced mainly by helper T cells and natural killer cells.

Natural Killer (NK) Cells

Natural killer cells descend from blood stem cells, and although natural killer cells are members of the “lymphocyte” family – together with B cells and T cells – NK cells do not have receptors which are made by mixing and matching gene segments. Natural killer cells mature in the bone marrow as do B cells, but NK cells are short lived, with a half-life of only about a week.

NK cells are not sentinel cells like macrophages, which hang out in our tissues and wait for invaders. Indeed, very few NK cells are found in tissues that are not under attack. Like neutrophils, NK cells are “on call,” and most NK cells are found in the blood or in the spleen and liver (two organs that store blood). Natural killer cells use the “roll, stop, exit” strategy to leave the blood and enter tissues at sites of infection, and once in the tissues, NK cells proliferate rapidly to build up their numbers. When they reach the battleground, natural killer cells can play two roles in defending us against infections. First, when NK cells receive battle signals from other immune system cells, they can give off cytokines that help with the defense. In addition to functioning as cytokine factories, natural killer cells can destroy tumor cells, virus-infected cells, bacteria, parasites, and fungi. NK cells kill these cells by forcing them to commit suicide. In some cases, NK cells employ an “injection system” that uses perforin proteins to deliver “suicide” enzymes (e.g., granzyme B) into a target cell. In other situations, a protein called Fas ligand on the NK cell surface interacts with a protein called Fas on the surface of its target, signaling the target cell to self-destruct.

To make the innate system work efficiently, there must be cooperation between players on the innate team. The IFN-γ produced by NK cells can prime macrophages, which can then be hyperactivated. When a macrophage is hyperactivated, it produces lots of TNF. A macrophage also has receptors on its surface to which this cytokine can bind, and when TNF binds to these receptors, the macrophage begins to secrete IL-12. Together, TNF and IL-12 influence NK cells to increase the amount of IFN-γ they produce. And when there is more IFN-γ around, more macrophages can be primed.

While the innate immune system uses hard-wired, pattern-recognition receptors to detect pathogens which also plagued our ancestors, the adaptive immune system is set up to remember attackers we encounter during our lifetime. This basis allows vaccines to be long effective after initial administration. The complexity of the adaptive system relies on antigen (alienated cells) binding and presentation to activate downstream cellular signals. B and Helper T cells govern this process.

B Cells
B-cells are like archers. They produce antibodies (small proteins that float around the entire body that very specifically recognise a particular kind of infection or abnormal cell). When an antibody sticks to a target, it acts like a flag and attracts the attention of other immune cells that then destroy the abnormal cell or bacteria. Vaccines work by instructing B-cells to make antibodies against a particular bug or virus. These are so specific however, that even small changes in the bug or the abnormal cell mean that the antibody doesn’t work. For example, this is why you need to take a new flu shot every year; as the influenza virus evolves and changes, so to must we evolve and change the vaccine to give us protection.
T Cells

T-cells don’t make antibodies, rather they make a similar kind of protein that sticks to the outside of the T-cell that is then used like a flashlight to examine each cell that the T-cell comes in contact with. T cells contribute to immune defenses in two major ways: some direct and regulate immune responses; others directly attack infected or cancerous cells.

Helper T cells, or Th cells, coordinate immune responses by communicating with other cells. Some stimulate nearby B cells to produce antibodies while others call in microbe-gobbling cells called phagocytes. Phagocytes are large white cells that can swallow and digest microbes and other foreign particles.

Components of the immune system communicate with one another by exchanging chemical messengers called cytokines. These proteins are secreted by cells and act on other cells to coordinate an appropriate immune response. Cytokines include a diverse assortment of interleukins, interferons, and growth factors. Some cytokines are chemical switches that turn certain immune cell types on and off.


Supplementation with a soluble B-Glucan exported from Shiitake medicinal mushroom, Lentinus edodes

(Click here to access full article)

This study investigated the effect and safety of β-glucan from L.edodes mycelium, in healthy, elderly subjects.

A total of forty-two healthy subjects (both male and female) aged 65 and over participated in a placebo-controlled, randomized, double-blind trial and were randomly allocated to two groups given either 2.5mg/day LENTINEX® or a cellulose placebo orally for six weeks. When a subgroup with pre-treatment values below the group median at entry was analyzed, a highly statistically difference in response in B-cells was observed

Research and Clinical Trials: Animal Studies

(Click here to access full article)

An increase in B-cells were observed in early safety and efficacy studies in mice and rats. B-cells almost doubled in mice from 16% in controls to 25% after an oral intake of LENTINEX®. A similar effect was observed in a rat safety study conducted in Bergen, Norway, which also evaluated LENTINEX®.





Click here to download the LENTINEX® patient brochure



Educational Videos



What is LENTINEX®?

LENTINEX® is a unique natural health product that enhances immune function. It is a liquid product obtained from the fermentation of Lentinula edodes, more commonly known as the Shiitake mushroom. This clear, light brown liquid contains free glucose, protein and the ß-glucan polysaccharide Lentinan.

LENTINEX® is intended for use as a dietary supplement to help improve immune function. It is indicated for the optimization of immune cell performance to build a more resistant immune system, while providing energy and improving overall wellness.

What are ß-Glucans?

Lentinan, a β-glucan is the main biologically active substance found within medicinal Shiitake mushrooms (Letinus edodes). It is a high molecular weight polysaccharide organized in a triple helix structure. ß-glucans directly activate leukocytes to stimulate phagocytic, cytotoxic and antimicrobial activity as well as the production of pro-inflammatory mediators, which are necessary to effectively eliminate pathogens from the body.

Why do we need to improve our immune system?

As we age, normal functions of the immune system decrease. It is important to enhance body immunity to continue an active response against viruses and bacteria.

What benefits can I expect from LENTINEX®?

  • Increase in fitness and energy levels
  • Increased activation of Natural Killer (NK) cells
  • Increased production of B-cells (CD19+) and Lymphokine-Activated Killer cells
  • Increased production of cytokines such as interleukins (IL-1ɑ and IL-1ß) and interferon-ɣ (IFN-ɣ)
  • Increased platelet production
  • Suppression of prostaglandins leading to increased T-cell differentiation and suppressor T-cell activity

When do I start to see results?

Improvements generally begin within 6 weeks and increase with continued use.

Why can’t I get the same results from a standard, daily multivitamin?

Many market available drugs, including multivitamins, are not developed by physicians, nor have they been comprehensively tested for both safety and efficacy. Standard vitamins may work to improve immune response; however, a high dosage is needed. LENTINEX®, on the other hand, only requires 2.5mL (half teaspoon) and has undergone rigorous scientific testing. Therefore, you can expect more from our product, and you will experience the difference.

How different is LENTINEX® from other immune enhancement products?

Many immune enhancers available on the market are not clinically proven to deliver results and are not registered with a regulatory body such as Health Canada or the Food and Drug Administration (FDA). LENTINEX® however, is thoroughly tested and registered with Health Canada (NPN: 80049210). In addition, LENTINEX® is manufactured to the same high Good Manufacturing Practices (GMP) standards as a pharmaceutical product.

 Has LENTINEX® been clinically tested?

Yes! LENTINEX® has been clinically tested and greatly improves immune responses within 6 weeks. Our patented formula was tested via a randomized, double blind, placebo controlled clinical study. This research study demonstrated significant results between the product and control group.


What is the Recommended Use?

To help support and enhance normal immune function.

What is the Recommended Dose?

Take half a teaspoon (2.5mL) daily.

Should I take LENTINEX® with food?

LENTINEX® may be taken with food or mixed with beverages.

Can I take LENTINEX® with other drugs?

Yes, LENTINEX® can be taken with other drugs. LENTINEX® will not affect the efficacy of other drugs.

Can children take LENTINEX®?
No, LENTINEX® is not recommended for children


What are the Medicinal Ingredients (per dose)?

ß-Glucan (Letinula edodes – mycelia)       1mg

Does LENTINEX® contain stimulants?
No, LENTINEX® does not contain any stimulants, yeast, dairy or artificial colours.


Are there any known side effects with the use of LENTINEX®?

Beta glucans are Generally Recognized as Safe (GRAS) according to the FDA. There are no clinical evidence of toxic effects of beta glucans. All studies demonstrated that it is an absolutely safe and effective compound for counteracting immunodeficiency.

Does LENTINEX® interact with any drugs that I may be taking?
LENTINEX ® has no known drug interactions


Can I order LENTINEX® online or over the phone?
Yes, LENTINEX® can be purchased clicking the BUY NOW button above or by calling +1 905 286 9111.

Is LENTINEX® available in stores?
No, LENTINEX® is not available in stores. It is available for purchase online or by calling 1-905-5286-9111.

Do I need a prescription to purchase LENTINEX®?
No, LENTINEX® is available as an OTC nutritional supplement.

How much does LENTINEX® Cost?
One bottle of LENTINEX® (30 mL) costs $25.00

How do I pay for LENTINEX®?
We accept all major credit cards (Visa, MasterCard) including PayPal

How long would it take for the product to reach me?
Orders will be processed the same day they are received and will be sent through Canada Post. Please allow 3 to 5 business days depending on your location.

Will my personal information remain private after I order LENTINEX®?
Yes, the information you provide to us will remain private and will never be shared. We will not share your email address, phone number or any personal data.