MemoProve

Memoprove™ Tablets 

SKU: 83565900301
DIN: 80032761
SIZE: 30 Tablets
DIRECTIONS: Dose is 90mg, 1 tab per day.
INDICATIONS: Help support memory in age-related memory loss. Intended for adults 18 years of age or older.

PRODUCT DESCRIPTION

MemoProve™ is a revolutionary new natural health product that supports memory in age-related memory loss. It is clinically proven to improve memory, alertness, and concentration through the activity of a patented blend of neuropeptides.

MemoProve™ is unlike any other memory product

MemoProve™ contains a patented blend of Neuropeptides (small chains of amino-acids) that mimic nerve growth in a well-functioning brain. These neuropeptides, known as N-PEP-12™, counteract the neurodegenerative changes that occur throughout the normal aging process by providing protective and regenerative support for the neurons in the brain.

Most dietary products for memory are made from a blend of vitamins, oils, and herbs which only claim to support memory. These claims, however, are not backed by relevant scientific testing and evidence. MemoProve™ is the first and only science based dietary product made from a proprietary blend of Neuropeptides (N-PEP-12™) clinically proven to improve memory in published, peer-review studies.

Clinical Studies show that MemoProve™ protects and improves memory in just 30 days

What Can You Expect From MemoProve™?

MemoProve™ has been clinically shown to counter mild memory problems. According to the former Chief of Geriatric Psychopharmacology at the National Institute for Mental Health, MemoProve™ is the first product, in his opinion, to improve symptoms of mild age-related memory problems as measured both by improved neuropsychological test results and reports of improvement by study subjects.

In published clinical research, study subjects experienced the following improvements in just 30 days:

• Improved short term memory (15% or more on standard memory tests)
• Increased ability to concentrate
• A higher state of alertness
• Improved ability to retain new information
• Renewed confidence in memory
• Improved mental sharpness and clarity

These improvements represent a reversal of 10 years of short-term memory decline.

Who Can Benefit from MemoProve™?

 

• All adults with mild memory problems
• Stressed, overworked and sleep deprived people
• Anyone looking to improve their overall cognitive function

 

 

How MemoProve™ Works

MemoProve™ contains a patented blend of Neuropeptides (small chains of amino-acids) that mimic nerve growth in a well-functioning brain. These neuropeptides, known as N-PEP-12, counteract the neurodegenerative changes that occur throughout the normal aging process by providing protective and regenerative support for the neurons in the brain.

 

In published research, neuropeptides have been shown to:

• Counteract underlying processes that cause memory problems
• Improve memory function, alertness, and concentration
• Support optimal brain health and function
• Replenish age related neurochemical deficits
• Stimulate new brain cell production (Neurogenesis)
• Stimulate robust brain cell connections (Neuroplasticity)
• Protect existing brain cells and connections (Neuroprotection)
• Increase glucose transport and utilization by the brain
• Increase vitality and energy output of aging brain cells
• Boost mental performance

Together, these changes amount to a significant improvement in memory performance and cognitive function that has been clinically shown to begin in just 30 days

What is N-PEP-12?

N-PEP-12 is the first natural health product, clinically proven to effectively improve memory and reverse the effects of age related memory loss. Scientific evidence from experimental studies with N-PEP-12 clearly demonstrates its potent neuroprotective activity and its stimulating effects on synaptic density and neuronal plasticity. These actions are the foundation of N-PEP-12’s beneficial effects on cognitive function and memory performance which have been convincingly demonstrated in human studies.

N-PEP-12 is Clinically Tested

In placebo-controlled clinical trials, individuals taking N-PEP-12 for one month improved on objective and subjective assessments of memory. They performed better on neuropsychological memory tests and also experienced an improvement in their mental capabilities and memory performance.

In clinical trials, N-PEP-12 users experienced a significant improvement in short-term memory, their ability to concentrate, and also reported feeling more alert and found it easier to learn new information.

The observed effects of N-PEP-12 in clinical trials on memory performance and brain function, demonstrate its effectiveness at maintaining healthy cognitive function and combatting age related memory loss.

Manufacturing and Quality Control

Manufacturing

N-PEP-12™ is produced enzymatically from purified nerve cell proteins and consists of peptone-based neuropeptides. The manufacturing process of the peptones is in accordance with current Good Manufacturing Practices (GMP) guidelines for the pharmaceutical industry and has been inspected and certified by the Austrian Ministry of Health.

Quality Control

The characterization and quality control of N-PEP-12™ is performed using enhanced analytical test methods for the determination of amino acids, total nitrogen content and HPLC-peptide fingerprinting for comparative analysis of different batches of the product. These state-of-the-art quality control procedures ensure that a highly reproducible quality of the product can be guaranteed.

Supplement Information

One box of MemoProve™ contains 30 smaller-sized tablets

Recommended Use: Help support memory in age-related memory loss

Medicinal Ingredients (per tablet): N-PEP-12™ (Peptones)…..90 mg

Non-Medicinal Ingredients: Lactose monohydrate, microcrystalline cellulose, croscarmellose sodium, cellulose acetate phthalate, triethyl citrate, magnesium stearate, silicon dioxide, talcum, titanium dioxide, synthetic paraffin.

MemoProve™ contains NO stimulants, herbs, yeast, dairy, artificial colours, sugar or preservatives. It is also mild and well tolerated.

Directions: Take one tablet daily.

Cautions: This product is intended for adults 18 years of age or older. Pregnant and breastfeeding women are advised to consult with their healthcare practitioner prior to using this product. This product is not suitable for vegatarians.

Storage: Store at room temperature

MemoProve™ has been registered with Health Canada; the Health Canada NPN number is 80032761

Safety and drug interactions: MemoProve™ is safe, effective, and clinically proven to improve memory, alertness, and concentration. The peptides contained in MemoProve™ are found in most protein rich foods and are generally regarded as safe (GRAS). MemoProve™ has no known drug interactions and there is no evidence of any toxic effects of N-PEP-12 in clinical trials. Since its introduction, over 12 million dosages of N-PEP-12 have been taken by consumers without any safety concerns

MEMORY LOSS

Memory loss is part of the aging process. With increasing age, our physical and mental capabilities tend to decrease if left unattended. This typically begins with complaints of short-term memory lapses and the perception of a reduced capability to acquire new information. This widespread phenomenon is considered to be related to the normal aging process and it has been termed Age-Associated Memory Impairment (AAMI). It develops gradually and generally affects people above the age of 40.

Studies have found that close to 50% of individuals meet the criteria for Age-Associated Memory Impairment at the age of 50 and that this number increases to over 80% of individuals older than 80 years of age.

Although AAMI is considered to be part of the normal aging process, its effects on memory performance are truly worrying. Research has shown that our memory function declines between age 30 and 70 in the order of 50%. Furthermore, the observed cognitive decline that comes along with AAMI is associated with detectable morphological and structural neurodegenerative changes. These changes are known hallmarks of Alzheimer’s disease pathology.

What causes mild memory problems?

• Age: After age 25 short term memory, focus, and concentration begin to slow and continue to steadily decline over time, even in normal healthy adults.
• Other factors may accelerate the onset of mild memory problems including stress, sleep deprivation, depression, medications, and drug and alcohol abuse

How can MemoProve™ help?

MemoProve™ has been clinically shown to counter mild memory problems. According to the former Chief of Geriatric Psychopharmacology at the National Institute for Mental Health, MemoProve™ is the first, product in his opinion, to improve symptoms of mild age-related memory problems as measured both by improved neuropsychological test results and reports of improvement by study subjects.

In published clinical research, study subjects experienced the following improvements in just 30 days:

• Improved short term memory (15% or more on standard memory tests)
• Increased ability to concentrate
• A higher state of alertness
• Improved ability to retain new information
• Renewed confidence in memory
• Improved mental sharpness and clarity
• This improvement represents a reversal of 10 years of short-term memory decline

MemoProve™ boosts cognitive performance and fights age associated memory loss

Taking MemoProve and utilizing N-PEP-12’s neuroprotective benefits, represents a valuable approach to counteract the subtle but insidious cognitive decline associated with the aging process. This clinically proven natural health product can help to support healthy memory function and cognitive performance while minimizing the risk of developing Age-Associated Memory Impairment.

CLINICAL RESEARCH

MemoProve™ Protects Neurons Against the Neurodegenerative Processes That Occur During Aging

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Experimental studies were performed to explore the neuroprotective activity of N-PEP-12, the active ingredient in MemoProve™, in neuronal cell cultures. More specifically, primary cultures of cortical neurons were pre-treated with N-PEP-12 and subjected to various types of cellular lesions and stress that would simulate conditions that occur in the aging brain.

Lesions were induced with sodium cyanate to simulate cytotoxic hypoxia, L-glutamate to induce excitotoxicity, ionomycin to simulate chronic calcium overload, and colchicine to induce cytoskeletal disruption. Cellular viability was determined 24h and 48h after the experimental lesion and the results of N-PEP-12 treatment were compared to control cell cultures. The results strongly indicated a neuroprotective effect of N-PEP-12 with a dose-dependent protection of neurons in all lesion models. Cell viability was significantly increased by N-PEP-12 treatment as compared to control cell cultures.

In summary, the study demonstrates that N-PEP-12 is a potent neuroprotective agent that can protect vulnerable neurons against metabolic deficits, ischaemic episodes, and neurodegenerative processes that occur in the aging brain.

MemoProve™ Improves Memory and Learning Performance in Aged Animals

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In this study, the effects of oral intake of N-PEP-12, the active ingredient of MemoProve™, on memory and learning performance in comparison to placebo treatment, were investigated in aged rats. Rats are considered valid models for human brain aging because they develop age dependent cognitive loss of synapses and atrophy of the brain.

Approximately 18-month old rats were treated for three months with once daily oral administration of N-PEP-12. Memory and learning performance of the animals was assessed at 1, 2, and 3 months after the onset of treatment using the so-called Morris water maze paradigm, where animals are trained to find a hidden escape platform in a swimming pool.  After the last behavioural test, the animals were sacrificed and brain samples were collected for subsequent histological analysis of synaptic density in the hippocampal formation.

The results of the behavioural tests in the Morris water maze showed a statistically significant difference between the N-PEP-12 treated group and the control group (treated with saline). The animals treated with N-PEP-12 found the hidden platform in the Morris water maze much faster than the control group (Fig. 1).

Figure 1: Effects of N-PEP-12 on long term memory in aged rats.
Values indicate the mean difference in time rats needed to find the hidden platform ± SD.
Higher values indicate better test performance. **p<0.01.

The improved cognitive performance of the N-PEP-12 treated animals correlated with morphological changes in the hippocampus of the animals which showed an increase of synaptic density. These results are in total agreement with the observed cognitive effects.

Based on these results, it is suggested that the increase in synaptic density and plasticity may induce long term beneficial effects, and can potentially slow down cognitive performance decline with age or reduce the risk of memory decline in the elderly.

MemoProve™ Enhances Cognitive Function and Brain Bioelectrical Activity in Humans

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This study was performed to investigate the effect of a single oral dose of N-PEP-12 on brain bioelectrical activity and on cognitive performance in healthy elderly non-demented subjects. Six healthy elderly individuals with a mean age of 63 years and with subjective memory complaints were enrolled in this study. Cognitive function and the brain bioelectrical activity of the participants were tested before N-PEP-12 intake and 24 hours after administration of 180 mg of N-PEP-12 using a battery of cognitive evaluation scales as well as electroencephalography examination.

In all three memory tests, improvement of cognitive function was evident after N-PEP-12 intake as shown in the graph below. Highly significant improvement was observed in two of the tests, the Total Memory Score with approximately 30% improvement, and the Word Recognition Task. In the latter, a highly significant improvement of about 46% relative to the baseline performance was evident after intake of N-PEP-12.

Figure 1:  Effects of N-PEP-12™ on Memory Performance
Values represent mean error scores ± standard deviation.
Lower scores represent improvement; *p<0.05; **p<0.01.

Electroencephalographic measurements of the brain bioelectrical activity showed that the intake of N-PEP-12 increased the brain bioelectrical power ratio by increasing the fast alpha activity and decreasing the slow delta activity, leading to an acceleration of overall brain activity (Fig. 2). The increase in alpha frequencies is consistent with a potential enhancement in arousal attention mechanisms.

Figure 3 shows a significant decrease in EEG power ratio scores after the administration of N-PEP-12, thus confirming the accelerating effects of N-PEP-12 on brain bioelectrical activity.

Figure 3: Effect of N-PEP-11 on EEG Power Ratio Scores in health elderly subjects.
Average percent change from baseline values is also represented.

Overall, results from the clinical study indicate that N-PEP-12 acts as a potent activator of brain activity even after only a single oral dose. Importantly, no adverse effects were reported and the administration of N-PEP-12 was completely safe and well tolerated.

MemoProve™ is an Effective Alternative for the Treatment of Age-Related Memory Loss in Older Adults

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In this study, the effects of N-PEP-12 were investigated in a fully randomized, double-blind, placebo-controlled, parallel-group trial comparing a single 90 mg daily dose of N-PEP-12 with a placebo. 54 Study participants, volunteers 50 years of age or older suffering from mild memory loss, were enrolled in this study. The intake period was thirty days and cognitive evaluations were performed at baseline and at the termination of administration. Volunteers were randomized to receive N-PEP-12 or Placebo in a 2:1 ratio. Thus, 36 study participants received N-PEP-12 and 18 received Placebo.

The primary outcome measure was the Memory Score on the Alzheimer’s disease Assessment Scale-Cognitive which was obtained by summing scores on the three ADAS-Cog memory tests; the Word Recall, Word Recognition, and Delayed Recall tests. Secondary outcome measures included the Syndrome Kurz Test (SKT), Digit Cancellation Test, Digit Span Subtest from the Wechsler Adult Intelligence Scales, Verbal Fluency Test, and Sandoz Clinical Assessment Geriatric Scale (SCAG) to detect clinical changes in symptomatology.

As shown in Figure 1, a significant difference favouring N-PEP-12 was found on the primary outcome measure, the ADAS-cog Memory Score. Further, two of the three memory subtests that comprise the score, the Word Recall and the Delayed Word Recall task, demonstrated a significant effect of N-PEP-12 (p<0.02) on cognitive performance.

Figure 1: Differences between N-PEP-12 and Placebo on memory tests.
**p<0.01, *p<0.05

Differences between the two groups were also shown in the secondary outcome measures. More specifically, a significant superiority (p<0.01) of N-PEP-12 over placebo, was seen on the SCAG and the SKT scale.

In conclusion, results of this study demonstrated that N-PEP-12 is a safe and effective compound for counteracting mild memory deficits that occur so frequently in later life. It is of interest that subjects with N-PEP-12 intake over one month improved relative to subjects with placebo intake, both on objective and subjective assessments of memory. Subjects not only performed better on neuropsychological tests but also perceived subjective improvement of their mental capabilities and memory performance.

MemoProve™ Improves Self-Perception of Cognitive Performance in Healthy Volunteers

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The activating effects of N-PEP-12 were confirmed in a self-assessment study in 20 elderly volunteers. In this study, 20 healthy elderly volunteers (15 female, 5 male) with subjective memory complaints resembling Age Associated Memory Impairment (AAMI) were taking a once daily dose of 90 mg N-PEP-12 for 28 days. The average age of the study participants was 59 years. A self-assessment questionnaire was used to assess the effects of N-PEP-12 in this study. The participants had to answer 29 questions related to their memory performance, their ability to concentrate, their learning capabilities, and their general well-being in a four point scale. This questionnaire was used before the onset of N-PEP-12 intake and at the end of the 4-week test period.

As shown in the figure below, significant improvement was evident after the one month intake of N-PEP-12. Overall, 18 participants out of 20 (90%) had improvement in at least one of the domains, 70% had improved memory function, 45% reported better concentration, 30% noted that their ability to learn had significantly increased, and 60% reported a generally better well-being. It is noteworthy that many of the participants wanted to continue taking Memoprove™ because they felt it helped them improve their mental capabilities.

Figure 1: Effect of N-PEP-12 on self-assessment scores
Values represent % participants who reported improvement after taking Memoprove™ (N-PEP-12) for 28 days.
Additionally, no adverse events were reported by the participants in the course of the study. This observation was confirmed by a general clinical examination of the patients at the end of the study.

In conclusion, the results of this study indicate that:

  • Healthy elderly subjects suffering from AAMI experience subjective improvement of memory performance after only one month of treatment with Memoprove™
  • Memoprove™ treatment is absolutely safe and well-tolerated

MemoProve™ Advantages in Comparison to Other AAMI Treatment Approaches

Relatively few peer-reviewed journals have published AAMI trials. The table below lists alternative therapeutic approaches for AAMI, along with results from a clinical study with MemoProve™:

(1) Crook TH, Ferris SH, Alvarez XA, Laredo M, Moessler H. Effects of N-PEP-12 on memory among older adults. International Clinical Psychopharmacology. 20: 97-100; 2005.
(2) Crook TH, Tinklenberg J, Yesavage J, et al. Effects of phosphatidylserine in age-associated memory impairment. Neurology. 41:644-649, 1991.
(3) Van Doegen MC, van Rossum E, Kessels AG, et al. The efficacy of gingko for elderly people with dementia and age-associated memory impairment: new results of a randomized clinical trial. J. Clin. Epidemiol., 56:367-376, 2003.
(4) Spiers PA, Myers M, Hochanadel GS, et al. Citicoline improves verbal memory in aging. Arch. Neurol., 53:441-448, 1996.

Based on the findings listed above, N-PEP-12, the active ingredient in MemoProve™, appears to be the first compound which leads to both subjective and objective improvement of memory performance while exhibiting a sound safety profile.

It is also important to mention that several memory supplements claim to have scientific studies supporting their effects but in almost all cases, these studies have been performed with individual components of these products only, often at dosages that are irrelevant to the human use. In contrast, all human studies with N-PEP-12 were conducted with the final product at the dosage that is recommended by the manufacturer.

RESOURCES

Brochures

MemoProve™ PATIENT BROCHURE

Click here to download the patient brochure

MemoProve™ INFORMATION BOOKLET

Click here to download the information booklet

MemoProve™ PRODUCT INFORMATION SHEET

Click here to download the product information sheet

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PRODUCT MONOGRAPH

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FREQUENTLY ASKED QUESTIONS

GENERAL INFORMATION QUESTIONS

What is MemoProve™?
MemoProve™ is revolutionary new natural health product that supports memory in age related memory loss. It is clinically proven to improve memory, alertness, and concentration through the activity of a patented blend of neuropeptides. Clinical Studies show that MemoProve™ can protect and improve memory in just 30 days.

What is N-PEP-12™?
Memoprove’s™ N-PEP-12™ is a unique food product ingredient and natural health product that supports healthy mental performance. It is a patented blend of peptone-based neuropeptides (small chains of amino acids) that support the effects of neurotrophic factors in the brain. The neuropeptides in N-PEP-12™ are derived from natural protein sources. N-PEP-12™ is safe, effective, and clinically shown to support healthy brain function and to improve memory, alertness, and concentration.

Do we lose memory with age, if so, why?
We all lose memory as we age, some faster than others. There are, however, a number of factors that affect the memory- loss process including diet, stress levels, physical exercise, and sleep.

What benefits can I expect from MemoProve™?
In published clinical research, study subjects experienced the following improvements in just 30 days:

  • Improved short term memory (15% or more on standard memory tests)
  • Increased ability to concentrate
  • A higher state of alertness
  • Improved ability to retain new information
  • Renewed confidence in memory
  • Improved mental sharpness and clarity

These improvements represent a reversal of 10 years of short term memory decline.

When do I start to see results?
Improvements generally begin within 30 days and increase with continued use.

Why can’t I get the same results from a standard, daily multivitamin?
Most mass market nutritional products, including multivitamins, have not been developed by physicians, nor have they been scientifically scrutinized the way our product has been tested – both for safety and efficacy. Standard daily multi-vitamins may work to improve overall health, however, they are not targeted specifically towards fighting memory loss. Memoprove™, on the other hand, having undergone rigorous scientific testing, is clinically proven to effectively combat age associated memory loss. Therefore, you can expect more from our product, and you will experience the difference.

How different is MemoProve™ from other memory products or brain foods?
Other memory products or brain foods on the market have not been clinically proven to deliver results and are not registered with a regulatory body like Health Canada or the Food and Drug Administration. Memoprove™ however, is clinically tested and registered with Health Canada. The Health Canada issued registered number is NPN: 80032761. As well, Memoprove™, unlike other memory products, is manufactured to the same high Good Manufacturing Practices (GMP) standards as a pharmaceutical product.

Has MemoProve™ been clinically tested?
MemoProve™ has been clinically tested and has been clinically shown to improve memory within 30 days. Our patented formula was tested using what is commonly recognized as the “gold standard” for scientific research: a randomized, double blind, placebo controlled clinical study. This clinical study was conducted on humans by an independent, third party scientific organization that specializes in dietary product testing. Results from the study were positive. Statistically significant results were demonstrated by the test (product) group relative to the control (placebo) group. Many memory products claim to have scientific studies supporting their effects but in almost all cases, these studies have been performed with individual components of these products only, often at dosages that are irrelevant to the human use. In contrast, all human studies with N-PEP-12™ were conducted with the final product at the dosage that is recommended by the manufacturer.

TAKING MEMOPROVE™ QUESTIONS

What is the recommended use?
To help support memory in age related memory loss.

How many tablets do I take in a day?
Take one tablet daily.

Should I take MemoProve™ with food?
MemoProve™ can be taken with or without food.

Can I take MemoProve™ with my vitamins?
Yes, you can take MemoProve™ with vitamins. MemoProve™ will not affect your vitamins.

Can children take MemoProve™?
Memoprove™ is suggested for anyone over the age of 18.

HEALTH AND SAFETY QUESTIONS

Are there any known side effects with the use of MemoProve™?
Peptones are Generally Recognized as Safe (GRAS) according to the FDA. There is no evidence of any toxic effects of N-PEP-12™ in clinical trials. The studies performed with N-PEP-12™ demonstrate that it is an absolutely safe and effective compound for counteracting the cognitive performance decline related to Age Associated Memory Impairment.

Does MemoProve™ interact with any drugs that I may be taking?
MemoProve™ has no known drug interactions.

PURCHASING QUESTIONS

Can I order MemoProve™ over the phone?
Yes. You call toll free at : 1-855 MINDCAL (1 -855-646-3225) or +1 905 286 9111

Is MemoProve™ available in stores?
No. MemoProve™ is only available online through our website or by calling the number above.

Do I need a prescription to purchase MemoProve™?
No. Memoprove can be purchased without a prescription.

How much does MemoProve™ cost?
1 pack is $49.95 plus $9.95(Shipping and Handling). If you buy the 3-Pack Option you save 21% and if you buy the 6-Pack Option you save 25%. For the 3-Pack and 6-Pack Options you pay a Flat Fee for Shipping and Handling of $9.95

What is Auto-Renewal?
With this program, we will automatically deliver 3 boxes of MemoProve™ to you every three months at an agreed date and charge your credit card. You will be saving on every carton of MemoProve™ for being a member of this plan and will also enjoy the convenience of auto-shipment. In the event that you decide to leave the program, all you have to do is email customerservice@memoprovememory.com or call our Customer Service at 1-855 MINDCAL (1 -855-646-3225) or +1 905 286 9111 during our opening hours 9.00EST to 5.00 EST, and we will take care of your request.

How do I pay for MemoProve™?
We accept all major credit cards (Visa, MasterCard), PayPal, certified cheques, and money orders. If you wish to pay by certified cheque or money order, please call Customer Service at 1-855 MINDCAL (1 -855-646-3225) or +1 905 286 9111.

How long would it take for the product to reach me?
Orders will be processed the same day they are received and will be sent through Canada Post. Please allow 5 business days depending on your location.

Will my personal information remain private after I order MemoProve™?
Yes, the information you provide to us will remain private and will never be shared. We will not share your email address, phone number or any personal data.

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